I have been on letrozole and Verzenio (abermaciclib) since May 2021 and I’ve had various side effects. This year I have had itchy skin on and off. On the nights where it prevents me from sleeping I take a phenergan which stops the itch and at the same time helps me sleep. My treatment has been successful thus far with my bone lesions having shrunk or stabilised and my cancer markers have gone from 313 before treatment down to 75 so I’m not prepared to stop treatment. I also take Panadol osteo on the days when bone aches tend to slow my movement. Good luck to everyone, I hope your treatment gives you many years to enjoy life to its fullest.