I think you have contributed a lot already - a lot. Sounds like you have done it tough but still showed up - that’s really fantastic. You absolutely don’t need to do more. Opt out. Look after yourself. There is absolutely nothing wrong with that. I would focus on what you have already contributed to the field and be proud of that. That in itself is so much more than for eg I have done. And I also think that leaving the trial is in itself good information for the trial. So even that will contribute especially if you feel able to be really honest about why you are exiting. And finally, women tend to feel so much responsibility and we continually keep going. I think a man would have given it the flick a long time ago and not persevered through hardship like you have. It is more than time for you to think of yourself and your kids. All the very very best ❤️.