Hi @Angelo, I started my journey here in Oct 2018. I'm on letrozole, ribociclib and denosumab. Its taken 6 months of trial and error with changing blood test results and for my immunity levels to "sort of" settle. I'm now on the lowest dose of ribociclib. So far, my results have been positive and my fatigue factor only really gets me on my "rest week" from the ribociclib funnily enough. I'm learning that eating well and exercise, walking, walking, walking, is helping me very much to cope with the fatigue. My first restaging scans showed "significant improvement" in my breast tumour but remained silent about my lymph nodes and spine tumours - so we took that as a win :) I'm going for another round of restaging scans in approx 3 weeks, so it will be interesting to see what they show - I'm trying not to dwell/worry too much about that, but it is hard. I'm still working full time, because I can and because I want to. And otherwise, I try to keep as busy as I can with all the things in life that I enjoy and care about, no time to waste anymore :) I live in a lovely suburb with lots of lakes around, so I try and do at least a 30min walk every day/every other day or more when I can. It does really help. Put on your ipod with your favourite music and off you go... I has really helped me. Hang in there, big hugs to you (()) Cheers xo