You have certainly done well on Xeloda @Sajani - I didn't realise there could be long-term problems. I have been on Xeloda for one year, it is keeping things stable - and, like you, I have been fortunate to not have too many side effects. So I'm hoping to stay on Xeloda as long as possible. My Stage 4 diagnosis was 2016, and prior to Xeloda I was on hormone therapy (Femara, then Aromasin, then Aromasin/Afinitor), which stopped working after a couple of years. But my oncologist has suggested that we will probably try hormone treatment again (probably with a CDK inhibitor) if the Xeloda becomes ineffective. I guess you have to be guided by your oncologist's advice - please keep us posted. Sorry I can't be more helpful, hopefully there may be someone on this forum who has faced the same problem with long-term Xeloda.