I have been reading other people's comments about hormonal treatment. I've been on Femara for nearly 4 years and apart from the predicted impact on bone density, I don't seem to have had any noticeable side effects. Mercifully my bone density was very good to begin with and my oncologist thinks I'll get through 5 years without too much damage (will worry about 10 years if and when that happens). I have had a couple of bad falls in that time ( just a slippery footpath and a stupid stumble) but no fractures at all. I do get thatnfeeling of dread in the pit of the stomach sometimes but that's the only symptom of a very occasional tachycardia attack ( I got an arrhythmia after surgery and chemo). The variety of experiences is staggeringly large!