Hi @Kiahdee. I have been on Kisqali and Letrozole for 16 months and feel very blessed. This drug combo has been very easy on me and has thus far done an amazing job of reducing my lesions in bones and liver. I am now down to 2 tablets of Kisqali for 2 weeks, then a week off. This seems to be my sweet spot, after suffering from low white cell counts on the full dosage. I have blood test monthly and scans every 6 months. I see my onc every 2 months. I run, I work full-time, and I keep up (mostly) with a busy, full household. My hair is a little thinner, so like @Glynnis I cut it very short. Overall, I feel brilliant and I almost forget that I have a chronic illness. Good Luck!!