@Cath62 i have CT scans every 4 months funny the ct didn’t show up my bone mets the bone scan spotted it first. I was on bone scan annually but for now they are they’ve chucked it back in the 4 monthly routine. Also originally the blood tests didn’t show any marked rise in my cancer markers till 3 months after the first sign of possible metastatic disease it was when the osteoblastic activity increased and the size of the area increased so did the cancer markers go up that confirmed the metastatic bone lesions. Because of where they are it wasn’t recommended doing a biopsy besides being extremely painful to have done. I remember having both a ct and bone scan at 6th month after end of original treatment it was mainly done to get a new base line and it was just as well it was done. My 1st radiation oncologist blamed arthritis for the changes. Just as well my medical oncologist ignored him and went with her own judgment or it could have been much worse before i went into 1st line of treatment for mets