Hullo @LEEMA I am 74 and have had very visible Dupuytens for several years now, long before I started on Femara 2 years ago. But I think it has become a lot worse since then. It is also known as Viking Hand and has strong genetic links with Norse ancestry. Actor Bill Nighy has it very badly, he hides his right hand in all his movies. I hadn't heard of radiation as a treatment and apparently surgery is not always successfull. I just live with mine and when bad soak hand in hot water and Epsom Salts, also massage with emu oil. Not really disabling, I can type and knit fine but grip is poor. I pointed my DC hand out to my surgeon and onco but nobody seemed very interested. Strange hard lumps on the soles of the feet are also a symptom. Good luck with your treatment.