Hi @Heton, I took Tamoxifen for 4 yrs. It’s been around the longest and is reasonably safe.A friend of mine who took it had no problems at all.Me, however, had terrible hot flushes,low mood and problems sleeping.I took another drug called Endep(10mg) to counteract those effects and it helped.I found the brand Genox was best for me as the other ones caused a rash.I would say get liver function blood test before you start as Tamoxifen began to affect my liver enzymes after 4yrs and I got a fatty liver.Otherwise I tolerated this drug but couldn’t have taken it for 10yrs as suggested.You can only try it and see how you go.