Hi there @kamada. All I can add it this. I had a total hysterectomy at age 28 and blood tests at age 37 found me to be very much post menopausal,,,like years before, I was told. As well, I've been on prednisolone for over ten years now due to an autoimmune disease which damages all the connective tissues in my body..particularly the joints, tendons and blood vessels. Another autoimmune disease has me on warfarin, which means I cannot take non steroidal anti inflammatories Add letrozole to the pot, stir and serve, and the result is (no surprise) I have very bad osteoporosis. Three rib fractures at different times without fall or injury. I've been on Prolia injections since 2017 and my jaw has yet to rot or fall to pieces. (Sorry about that my dear hubby....but you can still hope that something will eventually stop the yabbering from me). I've had some improvement in my bone density but am still osteoporotic...just bad now rather than shockingly so. I use a wheeled granny walker when out of the house as I know if I fall, then that would be a disaster. I have very few side effects other than about a week after having it, I get the collywobbles and feel quite nauseous. It passes in about three or so days.