Dear @sooziqu
i’ve been on Letrozole for eight years, it takes a while to work out what is a short term reaction and what is longer term and three days is hardly enough to do either. All sorts of things can conspire (having cancer for a start) to sleeping badly and feeling low! As you say, you have other issues to find out about, and certainly osteoporosis is a factor in taking an AI, so maybe you need to discuss your concerns further before ditching an AI. I am all in favour of personal choices about medications and quality of life but like @iserbrown, I think 13 - 17% is quite considerable. Best wishes for your forthcoming meeting.
