Tamoxifen has been ok for me. At the 4 week mark I had a significant weird thing happening: hot flushes, insomnia, depression, anxiety, i dropped the dose (without consultation) to 10 mg every other day, then after about 2 weeks, once my moods had stabilised I went back to the full20mg dose and I have been completely fine since - a few hot flushes at night and some insomnia, but depression and anxiety largely gone. I try to exercise every day - walking mainly. Overall I'm finding the tamoxifen very "do-able".