I do not take hormone suppressants however have leg cramps from PN. Sometimes they were so bad I would pace the floor for hours as staying in one spot was excruciating. I wasn't allowed ibuprofen but some nights I took it anyway as the pain was beyond description. It helped HEAPS. According to the research, ibuprofen has no counter/interaction with Tamoxifen. Worth a try when it gets unbearable. Ibuprofen has never helped with any other pain I have had and I never take it for any other purpose. Hopefully you find something that works for YOU. Vitamin B may also reduce the pain.