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Brenda5's avatar
Brenda5
Member
8 years ago

Tamoxifen 10mg

With all my odd side effects on 20mg Tamoxifen over the last 2 years I asked my oncologist last year, could I have a break? The answer was no.
Recently I had tachycardia (180 beats per minute) but the interesting thing is to keep it in check I require only 1/4 tab twice a day of 50mg Metoprolol. My GP is astounded it has such an effect on me and says I must be very drug sensitive since my chemo. He said he has had patients take two full tablets a day and it still doesn't regulate their heart properly.
I tried last year taking Escalopram as per my psych doc and couldn't tolerate even half a tab of that as I had diarrhea for weeks with it so we dropped it.
I had been taking a half of a 100mg dose of aspirin as an offset to Tamoxifen giving me vein troubles in my eye and emergency, during my heart episode, told me to increase to a full tablet daily. After a few weeks of it, I have had to reduce it back to a half dose again as I was having deep dark looking bruises coming up for no good reason on my legs and arms. Since reducing it to a half, things have been good again.


I thought to myself, I have been on Tamoxifen religiously at 20mg for exactly two whole years. I have finished menopause and perhaps I don't actually need the full 20 mg any more? So as of a few days ago, I am doing a self trial of half a tablet of Tamoxifen daily. I think my body has been knee jerk reacting to this drug for the last two years so maybe a lesser dose will be a happy medium for my body. At least a box of pills will last twice as long. The Metoprolol box lasts me over 200 days! lol.

11 Replies

  • Brenda how would you tell if it was working or not? That's the biggest  issue. Unlike the other drugs where you can see changes and monitor. The only way with tamoxifen to know if not enough is if the breast cancer returns. If really wanting an alternative to it perhaps  its time to revisit changing to an AI instead. 

    You need to discuss the reduced dose with your Doctor. Drug sensitive is different really to supressing hormones. I know for instance with letrozole...all women on same dose. ..whether they have huge amounts of body fat or not. The medication is not weight dependent or symptom dependent like other medications.