Hello my background is bc infilit duct grade 2 20mm with one lymph node .8 mm dr positive, or positive her2 neg. treatment lumpectomy, radiation and now on tamoxafen. I didn't really question tamoxafen as my oncologist said that and surgery were the two biggest interventions for me. I didn't read the side effect profile as I thought I don't want to be influenced! I did have initial side effects which resolved : seem to remember especially after eating curry and drinking coffee: neither of which I was going to give up. I do try to balance benefit and 'cost' but encourage a questioning : I only commenced tamoxifen a good month after radiation stopped : in part to commence when I had recovered from one treatment before another . I do feel a bit less dynamic and the absence of libido! And liked how oncologist raised idea of 6 week tamoxafen holiday: and also talked about balancing out fear oriented part of discussion by saying if your cancer is going to come back in 6 weeks then ...? I'm not ready to take a 6 week tamoxafen holiday but good to know somewhere before refusal there are some other strategies. I did forget it in the last week and had a little panic about what I should do can I take two in one day before realising i was coming from fear and just stopped. I read in the paper awhile ago that luck seems to be behind most of us getting cNcer and I found that comforting in a way and seems to balance out that despite all of our interventions there are no guarantees !