@Milly21 You are lucky you could tolerate 20mg for as long as 6 years before it got too much. 15 weeks is all I could take before the oncologist dropped my dose to 10mg. Then another 15 weeks and he dropped it altogether. Unfortunately that didn't work either as four months later I had a recurrence. He now says we have to find a way to stay on it. So I'm now on 10mg every second day (equiv 5mg) and will take regular breaks from it when it gets too much. Better to be on something than nothing but I can't say if it will be successful. There's not many options as I'm only in my 40's, but they have had success in American studies so I'm hopeful.