Greetings. I feel all your pains (having experienced most of them) but it does get better and I am grateful every day I get to take something that halves my risk of it coming back. In fact I plan to take it for ten. There's no easy solution: I take mega doses of fish oil and vit d, hardly ever drink alcohol and eat healthy as much as possible (but by no means a paragon of virtue). It's been about 18 months now and the side effects have lessened: I still walk like a 90 year old for the guest few steps if I've been sitting for a while; I'm talking to my oncologist about the ankle swelling I'm experiencing at the moment this coming Wednesday; I find I'm suffering one side effect or other at all times (golfers elbow at mo) but I'm still here and I'd be way too scared to stop doing my meds. I'm really sorry you're having such a hard time with ... but I really hope you persevere for longer. Whenever it's bad I tell myself: how would I feel if it came back and I hadn't done everything to try to stay healthy? Oh, and for fatigue: exercise always works for me. Swimming the best. I get out if the pool or ocean and feel I can do anything. In my case the side effects come and go. One flares up. Another does down. Another one comes back. Are yours all at the same time? :-( xo