Here is some Research I came across...

Sheryl absolutely, and I think we know our limits don't we? not having my kids around has tipped me to be honest, not coping and after 6yrs hard slog raising them, but I want them to do well and theyre not far away and will visit. Timing just sucks I guess. So am looking forward to friday my appointment. Im so glad you did that too! as its hard to find a good outlook sometimes especially with whatever your diagnosis is. Hugs xo 

i have decided not to have Tamoxifen just yet.. I have just finished Radiotherapy 3 weeks ago.. I will get another blood test done very soon and keep an eye on my estrogen levels... mine was ER positive and Testosterone positive but HER2 negative... dont think my Oncologist will be happy but we will work around it.. apparently im Post Meno as well and didnt even know until my last blood results came back in Nov..  

Hey All!!! yes sneaky little buggers, unbelievable but so great that they are working this stuff out, because its going to help us all so much! Sheryl! That is CRAZY!!!! I believe thats what happened too with my recurrence, it stopped working, which is alarming and I had Radiotherapy too, so at the time Im like how??? but the more they learn and know the better they are going to get at developing better treatments and that is what we absolutely want!!! Sheryl I think you're incredible, honestly! after everything youve been through and continue to go through. Let us know how you go with your Oncologist! Thanks Sheryl!!! yes Im doing ok, had a very hectic stressful week and have decided to reach out to a Psychologist who I saw about 3 years ago who helped me through the sudden death of my Mum, and my marriage breakdown and then Breast Cancer all in 2yrs. Looking forward to nutting some things out with her about the Surgery and how Im feeling.

Big Hugs!!!! xoxoxo

Thanks Melinda - sneaky little buggers trying everything to get around current thinking and treatment ! 

When I was diagnosed with secondary bc with bony mets, I asked my oncologist  "why did it return when I had chemo, mastectomy, radiotherapy and continued years of Tamoxifen, Arimidex, Femara ( over my pre and post menopausal journey), when a bone scan 3 years earlier was clear?" I was told that sometimes the cell blockers simply stop working & the cells "switch back on". 

Crazy, frightening stuff though - I see my oncologist in 10 days time - I will certainly discuss this with her. 

Hope you are doing ok, @melclarity <3

Sheryl xx 

Thanks Melinda. At least they have discovered this and now can use the knowledge gained for more effective treatment.

Yes I read that. Horrible adaptive buggers. Bring on the research.

Exactly sends shivers right through me

Tamoxifen and aromatase inhibitors are completely different treatments. Both intended to starve hormone receptive cancers, but they do it in different ways.
Joy, oh joy, to hear this stinking disease has figured out a way around what I thought was my best chance of survival. 

Hi Rita,  my surgery is feb 27th x

Jane doing ok saw my exercise physiologist today struggled a little as 2 days on my feet at work really took its toll.

I thought it very interesting that 1/3 of cases Tamoxifen doesn't work. I also wonder too if this is what happened to me with my recurrence. Also why Arimidex works better my Oncologist said i wonder if thats because being oost menopause as chemo threw me into that. Whilst 4yrs on tamoxifen i never had bloods done and didnt have an oncologist only my surgeon as i had radiation only in 2011 after lumpectomy then tamoxifen. 

Deanne my take on the whole thing is like yours. Im glad theres so much research going on too! my friend will ask to switch to another inhibitor. She automatically thought of me and wondered if this possibly is what happened to me.  The research will help so much with this and hopefully stopping some recurrence.  

Iserbrown it does make you shiver but knowledge is power.  X