I started letrozole a week after I started 25 sessions of radiotherapy 12 weeks ago. I have suffered some nausea (my oncologist says this is not related to the medication) who knows, I am chewing on Buderim ginger lollies when I feel it is coming on. In the past couple of weeks I am getting quite painful joint pain and swelling fingers in my hands that has woken me at night and I now need to take my wedding rings off before going to sleep. It seems to settle during the day although my hands are stiff and I have been taking regular panadol osteoporosis (2 tablets, morning, afternoon and evening) plus rubbing fisio cream into my hands and finger tips. I also have peripheral neuropathy in my fingers and feet from 6 months of chemo. My yoga teacher showed me some hand yoga (mudras?) to do which stretches fingers which I am doing when I am a passenger in the car or just sitting at night watching TV. I never expected all these side effects and thought that I had managed the chemo very well (didn't get nausea etc) and got through the radiotherapy and now the whammy of side effects from letrozole. I know it is well researched to keep the cancer at bay for suppressing oestrogen. I am going back to the oncologist in 3 months whilst all of this is being monitored (gabapentin for the PN). She said it could be changed if the side effects were unbearable but I will see how I progress. As my daughter who is a consultant physician doctor says, "well mum you are still alive...." On at the good side, I got clear scans last week (after mastectomy in Aug with Lobular C) so that's VERY GOOD NEWS! Just the reconstruction op to have in Sept after the birth of my grand-daughter!