The prospect of taking medication that may have unpleasant side effects, for years, is perfectly rational. Your oncologist should explain why it is being recommended and the benefits he/she believes that treatment will provide. You should also ask about their willingness to change medication (different brand or type) if the side effects are severe. Some people get particular side effects from Letrozole, some get different ones, some get almost none. Unfortunately you have to start to find out which category you are in. Never underestimate the impact of what you have been through - tiredness is often a symptom of just being tired of it all. Not necessarily depressed, but definitely not as cheery as you may act. Keep an eye on it, it’s a side effect not often discussed. Best option for letrozole is to get as much information as you can, check your baseline (such as your bone density), start and see how you go. Best wishes.