I've been on femara for nearly 4 years and haven't had any symptoms, certainly not emotional distress. I agree with primek, the concentration on treatment can keep you clear of an emotional reaction (to the whole thing, not just treatment) until you actually stop and then you mentally have to catch up. And often people can't understand why they are reacting at this stage, when when they were coping so well earlier. I didn't experience the sad or apathetic reaction myself, but I felt the wind knocked out of me by realising (in the space of 6 weeks) that I had 3 long term side effects. My terrific oncology nurse recommended a counselor, and the counselor was excellent in helping me identify my real issues, get to terms with them and get back to a happy outlook on life in a very short time. Not depressed, no drugs, just got a tad overwhelmed. Sometimes you need an outsider, to help you focus again. Best wishes.