Cdk 4/6 inhibitor - node negative

Question

Hi all - has anyone been on a cdk 4/6 for early breast cancer in Australia while node negative but otherwise having relatively moderate-high risk (eg stage 2, grade 2/3, high Ki67) hormone positive diagnosis?

mez_bcna · Answer

Hi Beginner​&nbsp;
While we wait for others to share their experience with you, please feel free to access our My Journey information on Targeted therapies for early breast cancer (If you haven't accessed previously).
Thanks for starting the conversation.

katie46 · Answer

Hi Beginner, my diagnosis was stage 2, grade 3, 1 lymph node involved. I've been taking abemaciclib since October last year as part of my ongoing treatment. It became available on the PBS towards the end of my chemo, and my oncologist was very happy he could include it as part of my preventative treatment, as I have a higher risk of reoccurance due to a ki67 of 30% the high grade of cancer, and the lymph node involvement. I'm assuming the lymph nodes don't have to be involved to qualify.&nbsp;

cactusk · Answer

Hi Beginner​&nbsp;I was prescribed Ribociclib for Stage 2B Grade 2 (and DCIS) (as well as Letrozole, Zoladex and Zometa) and was able to get this via the early access program (so only paid $31.60) through my medical oncologist. Unfortunately, after 5 months, I became very unwell due to a rare (but known) side affect which damaged my liver. It too over 3 months for my bloods to get back into the normal range and for me to feel better. My med onc has advised that going forward, there would be some issues if I needed to take another CDK4/6 medication, but (hopefully) that will be long into the future (if ever). From my readings on this site (and further) it seems some people are totally fine and have few side effects, whereas others, like me, don't. Do you feel OK on your CDK4/6?cactusk​&nbsp;

beginner · Answer

Thank you all for your responses. I am not on a CDK 4/6 inhibitor currently but will ask my oncologist about whether I should be at the next meeting in June.&nbsp;

sarahb77 · Answer

Yep, i've been on Ribociclib for a year now following chemo/rads/surgery due to high risk of recurrence. Did you have any specific questions?