Hello @WhiteLight - we get to make all these decisions with the medical information provided (or not) and it is difficult at times. Like you, I had severe osteoarthritis and that was the main reason I decided, with the blessing of the oncologist, to not take them. Other medications came into it after discussing the interactions with other drugs with the pharmacist. I preferred to opt for quality of life, not quantity of life. At the time I knew that it was my decision, the right one for me, and that I would have no regrets. That was almost ten years ago. All the best for your decision. PM me if you want more info. 💖