Would you take part in a clinical trial?
So I've been approached by my oncologist to take part in a clinical trial of drug called Ribociclib- from my understanding it is one that has been used in the last few years to treat metsatic BC with...
Forum Discussion
Ask your oncologist's opinion about the recent early termination of the PALLAS trial, which evaluated if palbociclib (Ibrance) could delay/prevent recurrence and improve disease-free survival in early BC patients, Palbociclib is a CDK4/6 inhibitor like ribociclib, and is effective in metastatic patients. Over 5,000 Stage II (IIa was limited to 1,000) and Stage III patients were enrolled - Stage I was excluded. Trial participants took palbociclib with endocrine therapy for two years, then continuing on endocrine therapy only.
PALLAS had been underway for about five years. The early termination, announced about two weeks ago, is due to a futility analysis determining the trial would not meet its objective. The failure of PALLAS has sent early BC researchers reeling because it's been thought that CDK4/6 inhibitors, impressive in the metastatic setting, could benefit early BC patients too.
You raise legitimate concerns about participating in a trial - travel and logistics, time commitment, tests, side effects - and as PALLAS demonstrates, perhaps with no benefit. Ask your oncologist's opinion about the commonalities and differences between PALLAS and the ribociclib trial offered to you. Best to you with your decision-making.
PALLAS had been underway for about five years. The early termination, announced about two weeks ago, is due to a futility analysis determining the trial would not meet its objective. The failure of PALLAS has sent early BC researchers reeling because it's been thought that CDK4/6 inhibitors, impressive in the metastatic setting, could benefit early BC patients too.
You raise legitimate concerns about participating in a trial - travel and logistics, time commitment, tests, side effects - and as PALLAS demonstrates, perhaps with no benefit. Ask your oncologist's opinion about the commonalities and differences between PALLAS and the ribociclib trial offered to you. Best to you with your decision-making.