Hi @Erko_Girl_68, I have been on the Verzenio since January. Similar to yourself I am at a high risk recurrence and was initially on a trial with the drug company before this was added to the PBS. I found the fatigue much worse than the D. Lasted 3 months on original 150mg twice daily before oncologist gave me a month off and reduced the dose to 100mg twice daily. The D was much better on lower dose but and had some much needed energy back, but after another 3 months and contracting covid fatigue was again an issue. (my white blood county has been affected much more than with the A/C or Taxol). I am about to start back on a reduced dose again after a month off and am not sure I will make the recommended 2 years, but aiming for at least a year. I'm not sure it is just the Abemaciclib to blame for the fatigue as I am suffering with hourly hot flushes and vertigo from the hormone treatment, but I have a friend who is a month into taking Verzenio and has reduced the dose to try and improve fatigue and D. Good luck, hopefully you tolerate the drugs ok. Feel free to check-in. It's rough going when you have already been through a lot, it's sometimes hard to know if it's worth continuing, I am taking in one month at a time.