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My oncologist was going to put m...","body@stringLength":"2631","rawBody":"I am in early stage B/C and have a high risk of recurrence (7 cm tumour in breast, 3 affected lymph nodes, 27 removed from armpit, hormone positive, Stage 3, Grade 2). My oncologist was going to put me on Ribociclib/Kisquali (3 years) along with Anastrazole (10 years) but then Ribo was recalled:
I was bummed because I read a bit about Ribo and understood the side effects. My onc recommended that I go on Abemaciclib/Verzenio for two years. Funny enough, I had been in a support group a few days earlier with b/c ladies and a McGrath Nurse and everyone was talking about how rough this drug can be on your gastrointestinal system.
My onc started me on 150 mg twice a day and their advice was to take loperamide (they said I would still have diarrhoea regardless). After ten days of cramps and daily diarrhoea, ranging from once to four times in one day, I advocated for a dose reduction to 100 mg twice a day. I have been on the reduced dose for three weeks, and I have experienced one extreme to another, diarrhoea or constipation. If I have the D, and take loperamide, for the next three or three or four days I have had constipation and have had to use a microlax/enema. Some days, I have constipation in the morning and D in the afternoon! Most days, I have stomach cramps ranging from mild to severe, where I am incapacitated for an hour. I have tried keeping a diary of my diet and my bowel movements to see if there is any pattern. I have seen a Dietitian specialising in oncology and used loperamide and a daily fibre to bulk my stools. Nothing I have done has made any difference because I have not had a normal bowel movement for the last month I have been on this drug. I have lost a lot of weight and having gastro-like symptoms just wipes me out with fatigue. Today, I am feeling 'Is it worth it?' after a morning spent lying on the bed with stomach cramps and D x 2. Verzenio has recently been added to PBS for ladies with early stage b/c and I wonder if there is anyone else in the same boat on this forum.
Can anyone tell me how long the symptoms (diarrhoea/constipation/cramping/fatigue) last? My oncologist said the D lasted up to three months and then intermittently for two years, which horrified me. ","kudosSumWeight":0,"postTime":"2024-06-07T21:36:39.000-07:00","images":{"__typename":"AssociatedImageConnection","edges":[],"totalCount":0,"pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null}},"attachments":{"__typename":"AttachmentConnection","pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null},"edges":[]},"tags":{"__typename":"TagConnection","pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null},"edges":[]},"timeToRead":2,"currentRevision":{"__ref":"Revision:revision:131732_1"},"latestVersion":null,"metrics":{"__typename":"MessageMetrics","views":108},"visibilityScope":"PUBLIC","canonicalUrl":null,"seoTitle":null,"seoDescription":null,"isEscalated":null,"placeholder":false,"originalMessageForPlaceholder":null,"messagePolicies":{"__typename":"MessagePolicies","canModerateSpamMessage":{"__typename":"PolicyResult","failureReason":{"__typename":"FailureReason","message":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","key":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","args":[]}}},"archivalData":null,"body":"I am in early stage B/C and have a high risk of recurrence (7 cm tumour in breast, 3 affected lymph nodes, 27 removed from armpit, hormone positive, Stage 3, Grade 2). My oncologist was going to put me on Ribociclib/Kisquali (3 years) along with Anastrazole (10 years) but then Ribo was recalled:
I was bummed because I read a bit about Ribo and understood the side effects. My onc recommended that I go on Abemaciclib/Verzenio for two years. Funny enough, I had been in a support group a few days earlier with b/c ladies and a McGrath Nurse and everyone was talking about how rough this drug can be on your gastrointestinal system.
My onc started me on 150 mg twice a day and their advice was to take loperamide (they said I would still have diarrhoea regardless). After ten days of cramps and daily diarrhoea, ranging from once to four times in one day, I advocated for a dose reduction to 100 mg twice a day. I have been on the reduced dose for three weeks, and I have experienced one extreme to another, diarrhoea or constipation. If I have the D, and take loperamide, for the next three or three or four days I have had constipation and have had to use a microlax/enema. Some days, I have constipation in the morning and D in the afternoon! Most days, I have stomach cramps ranging from mild to severe, where I am incapacitated for an hour. I have tried keeping a diary of my diet and my bowel movements to see if there is any pattern. I have seen a Dietitian specialising in oncology and used loperamide and a daily fibre to bulk my stools. Nothing I have done has made any difference because I have not had a normal bowel movement for the last month I have been on this drug. I have lost a lot of weight and having gastro-like symptoms just wipes me out with fatigue. Today, I am feeling 'Is it worth it?' after a morning spent lying on the bed with stomach cramps and D x 2. Verzenio has recently been added to PBS for ladies with early stage b/c and I wonder if there is anyone else in the same boat on this forum.
Can anyone tell me how long the symptoms (diarrhoea/constipation/cramping/fatigue) last? My oncologist said the D lasted up to three months and then intermittently for two years, which horrified me. ","customFields":[]},"Conversation:conversation:131732":{"__typename":"Conversation","id":"conversation:131732","solved":false,"topic":{"__ref":"ForumTopicMessage:message:131732"},"lastPostingActivityTime":"2024-07-19T16:56:41.000-07:00","lastPostTime":"2024-07-19T16:56:41.000-07:00","unreadReplyCount":4,"isSubscribed":false},"ModerationData:moderation_data:131732":{"__typename":"ModerationData","id":"moderation_data:131732","status":"APPROVED","rejectReason":null,"isReportedAbuse":false,"rejectUser":null,"rejectTime":null,"rejectActorType":null},"Revision:revision:131732_1":{"__typename":"Revision","id":"revision:131732_1","lastEditTime":"2024-06-07T21:36:39.000-07:00"},"ForumReplyMessage:message:131733":{"__typename":"ForumReplyMessage","id":"message:131733","conversation":{"__ref":"Conversation:conversation:131732"},"author":{"__ref":"User:user:20667"},"revisionNum":1,"uid":131733,"depth":1,"hasGivenKudo":false,"subscribed":false,"board":{"__ref":"Forum:board:general-treatment-and-surgery"},"subject":"Re: Verzenio blues","readOnly":false,"editFrozen":false,"moderationData":{"__ref":"ModerationData:moderation_data:131733"},"parent":{"__ref":"ForumTopicMessage:message:131732"},"body":"You are having a really hard time of it @Erko_Girl_68 :( Hopefully someone who's been on Verzenio will jump on soon & help you with advice. Can the dose be lowered a bit til you stabilise?
Can you contact your Breast Care Nurse to chat with the Onc & hopefully get some sort of solution to your trots/clogged up issues?
When hubby had diarrhoea from his chemo, he took Gastrostop/Loperamide with each loose motion & was lucky not to get the opposite clogging as well. There must be something your Onc can do to limit those highs & lows :(
take care & all the best
","body@stringLength":"682","rawBody":"You are having a really hard time of it @Erko_Girl_68 :( Hopefully someone who's been on Verzenio will jump on soon & help you with advice. Can the dose be lowered a bit til you stabilise?
Can you contact your Breast Care Nurse to chat with the Onc & hopefully get some sort of solution to your trots/clogged up issues?
When hubby had diarrhoea from his chemo, he took Gastrostop/Loperamide with each loose motion & was lucky not to get the opposite clogging as well. There must be something your Onc can do to limit those highs & lows :(
take care & all the best
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Damnit, just when I thought I was over it all...and it was found 4 weeks prior to my DIEP Recon. Thankfully, my beautiful GP referred me to a gorgeous Gynaecologist who fast tracked my treatment and had me in a couple of days later, fixing it all laparoscopically.
The pathology was normal. Yippee.
Hope yours gets resolved as quickly as mine did.
Nikki xxx","body@stringLength":"567","rawBody":"Hey @Dandelion...totally understand where you're coming from: I had something sort of similar...a uterine polyp though and something weird going on in one fallopian tube. Damnit, just when I thought I was over it all...and it was found 4 weeks prior to my DIEP Recon. Thankfully, my beautiful GP referred me to a gorgeous Gynaecologist who fast tracked my treatment and had me in a couple of days later, fixing it all laparoscopically.
The pathology was normal. Yippee.
Hope yours gets resolved as quickly as mine did.
Nikki xxx","kudosSumWeight":0,"repliesCount":0,"postTime":"2017-05-09T20:29:29.000-07:00","images":{"__typename":"AssociatedImageConnection","edges":[],"totalCount":0,"pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null}},"attachments":{"__typename":"AttachmentConnection","pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null},"edges":[]},"timeToRead":1,"currentRevision":{"__ref":"Revision:revision:133746_1"},"latestVersion":null,"metrics":{"__typename":"MessageMetrics","views":0},"visibilityScope":"PUBLIC","isEscalated":null,"placeholder":false,"originalMessageForPlaceholder":null,"messagePolicies":{"__typename":"MessagePolicies","canModerateSpamMessage":{"__typename":"PolicyResult","failureReason":{"__typename":"FailureReason","message":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","key":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","args":[]}}},"parent":{"__ref":"ForumTopicMessage:message:133745"},"replies":{"__typename":"MessageConnection","edges":[],"pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null}},"customFields":[]},"User:user:19847":{"__typename":"User","id":"user:19847","deleted":false,"uid":19847,"login":"Dandelion","biography":null,"registrationData":{"__typename":"RegistrationData","status":null,"registrationTime":"2017-03-27T03:40:21.000-07:00"}},"CachedAsset:text:en_US-shared/client/components/users/UserAvatar-1742938040000":{"__typename":"CachedAsset","id":"text:en_US-shared/client/components/users/UserAvatar-1742938040000","value":{"altText":"{login}'s avatar","altTextGeneric":"User's avatar"},"localOverride":false},"CachedAsset:text:en_US-shared/client/components/ranks/UserRankLabel-1742938040000":{"__typename":"CachedAsset","id":"text:en_US-shared/client/components/ranks/UserRankLabel-1742938040000","value":{"altTitle":"Icon for {rankName} rank"},"localOverride":false},"CachedAsset:text:en_US-shared/client/components/nodes/NodeIcon-1742938040000":{"__typename":"CachedAsset","id":"text:en_US-shared/client/components/nodes/NodeIcon-1742938040000","value":{"contentType":"Content Type {style, select, FORUM {Forum} BLOG {Blog} TKB {Knowledge Base} IDEA {Ideas} OCCASION {Events} other {}} icon"},"localOverride":false},"QueryVariables:ReplyList:message:131733:1":{"__typename":"QueryVariables","id":"ReplyList:message:131733:1","value":{"id":"message:131733","first":10,"sorts":{"postTime":{"direction":"DESC"}},"repliesFirst":3,"repliesFirstDepthThree":1,"repliesSorts":{"postTime":{"direction":"DESC"}},"useAvatar":true,"useAuthorLogin":true,"useAuthorRank":true,"useBody":true,"useKudosCount":true,"useTimeToRead":false,"useMedia":false,"useReadOnlyIcon":false,"useRepliesCount":true,"useSearchSnippet":false,"useAcceptedSolutionButton":true,"useSolvedBadge":false,"useAttachments":false,"attachmentsFirst":5,"useTags":false,"useNodeAncestors":false,"useUserHoverCard":false,"useNodeHoverCard":false,"useModerationStatus":true,"usePreviewSubjectModal":false,"useMessageStatus":true}}}}},"page":"/forums/ForumMessagePage/ForumMessagePage","query":{"boardId":"general-treatment-and-surgery","messageSubject":"verzenio-blues","messageId":"131732","replyId":"131733"},"buildId":"Btkyb7T6TeYM9D2gUmiOv","runtimeConfig":{"buildInformationVisible":false,"logLevelApp":"info","logLevelMetrics":"info","openTelemetryClientEnabled":false,"openTelemetryConfigName":"breastcanceraus","openTelemetryServiceVersion":"25.2.0","openTelemetryUniverse":"prod","openTelemetryCollector":"http://localhost:4318","openTelemetryRouteChangeAllowedTime":"5000","apolloDevToolsEnabled":false,"inboxMuteWipFeatureEnabled":false},"isFallback":false,"isExperimentalCompile":false,"dynamicIds":["./components/seo/QAPageSchema/QAPageSchema.tsx","./components/community/Navbar/NavbarWidget.tsx","./components/community/Breadcrumb/BreadcrumbWidget.tsx","./components/messages/TopicWithThreadedReplyListWidget/TopicWithThreadedReplyListWidget.tsx","./components/messages/RelatedContentWidget/RelatedContentWidget.tsx","./components/messages/MessageListForNodeByRecentActivityWidget/MessageListForNodeByRecentActivityWidget.tsx","./components/customComponent/CustomComponent/CustomComponent.tsx","./components/messages/MessageView/MessageViewStandard/MessageViewStandard.tsx","../shared/client/components/common/List/ListGroup/ListGroup.tsx","./components/messages/MessageView/MessageView.tsx","./components/messages/MessageView/MessageViewInline/MessageViewInline.tsx","../shared/client/components/common/Pager/PagerLoadMore/PagerLoadMore.tsx","./components/customComponent/CustomComponentContent/HtmlContent.tsx","./components/customComponent/CustomComponentContent/CustomComponentScripts.tsx"],"appGip":true,"scriptLoader":[]}