@KatherineH Hello! there is a number of threads on Tamoxifen it you put that into the search bar you can bring up all previous conversations. There was one as recent as 15/9. I was on Tamoxifen for 4yrs pre menopause, zero side effects, however I had a recurrence at the 4yr mark same spot, same breast even after radiation. Post the latest treatment have had more side effects with Arimidex and Aromasin, however the side effects moreso has been from chemo and menopause, the AI just adds to the mix, but honestly, it's just annoying I find than debilitating now. Hugs Melinda xo