Thanks Louise, I'm interested to hear any experiences of tamoxifen I can. I've done a lot of reading and thinking about this issue over the last couple of months and I've come to the conclusion that with my cancer - strongly estrogen positive and grade 3 - I can't afford to reject it. However, I want to be as well prepared as possible before I start taking it in a few weeks. I figure that the more I know the better I'll be able to deal with any side-effects. My biggest fears are weight gain (vain I know), insomnia and depression. But I guess I'll just have to see how I go. I want to get as fit and healthy as I can too, beforehand. Hopefully it won't be as bad as I fear. Most things aren't. Take care, Janet. :)