Hi @Christabel03, I started tamoxifen in November 2020 and stopped in June 2022 and switched to Letrozole because the side effects really got to me. We are all different and all react differently to these drugs.
My experience started off ok but I did notice the mood thing. It made me just feel flat. I thought I could manage that with exercise but the mood thing eventually got worse.
Far worse than the mood for me was fatigue and breathlessness. I was always a big walker but after 20 months on that drug I found i was struggling to even go up 10 steps. I thought I had a heart issue and got that checked and the all clear so it was just the tamoxifen effects.
My oncologist is pretty good and suggested I take a 6 week break and I started on Letrozole. Wow my life has improved 100%. No fatigue, no breathlessness and no mood issues. It's fantastic. I have a little hand pain but currently it is manageable. My oncologist is ok for me to switch again if the hand pain increases which is great.
Talk to your oncologist and discuss the side effects. If it gets too much see if another med would work for you.
Best wishes with your treatment.