Hi @MMAN, the treatment strategies are different for everyone and not everyone has side effects from all the treatments. I take tamoxifen and I am on this now for 1.5yrs so far. I have not gained weight really but naturally fluctuate 1 or 2 kgs. I dont I can loose weight. My oncologist suggested it is near impossible on tamoxifen. She also wants to discuss going on an AI next visit. Sometimes people start on one med and then go to another for various read. I initially had a few hot flushes when I started on this med and I do get fatigue, no hair loss. I think I was a little moody at the start but all that settled in a couple months. I am not sure if I am on tamoxifen or an AI for 5 or 10yrs yet. I try not to get too far ahead of myself and just stay in the moment. Good luck