It's been a year since I commented on this thread, so more than two years since starting to take Tamoxifen. Unfortunately my blood tests in mid-2014 indicated that I was still not quite post-menopausal so my onco wants me to remain on Tamoxifen and put me through the blood testing again mid this year. Only thing is the more time goes by the more the side effects get worse, in particular fatigue, leg pain and the hot flushes. I am headed away on an overseas trip with my hubby in mid-April and have decided that I am going to take a break from the Tamoxifen from now on in the hope that the side effects will subside and I can actually enjoy my month long trip. I have no plans to consult with my onco or GP. I'm just gonna do it! It will be interesting to see how quickly the side effects do go away, if indeed they do at all? I'll go back on it after the trip. Anyone else decided to take a break and how it turned out for them? Hugs, Vicki