I ran into serious reaction to paclitaxal straight after my second dose. I know a friend who is 2 years post her journey with severe nerve damage to this day and she warned me to speak up if I was concerned. I immediately rang to consult with my oncologist. My side effects were burning and the most excruciating itching that felt like I was being bitten by a gazillion fire ants! I cried hysterically and the only relief was to scratch and rub my hands and feet untill I almost drew blood. I just got so frightened and refused to continue because I thought if it was this bad after only 2 doses? so they stopped it immediately. I went back to my first lot of chemo and used that for the remainder of the period as my oncologist reconed it would be just as effective.