It is my understanding that some small studies have been done on this,but it is connected more to people that have a SPECIFIC genetic link for Alzheimer's,and even then ,this sort of information is from small studies,and in the early stages also.My grandmother died from Alzheimer's,but there is no way I would stop my Tamoxifen,as I believe that our doctors here in Australia have the very latest information regarding BC and risks of different treatments.I do know that it is possible to keep your brain active by doing things like crosswords,on a very regular basis.Reading is good also,but puzzles are better I think,because they work the brain.All the best with your choice,and I would be interested in hearing any information that you get from your doctor.Cheers Robynxox