Hi Andy, sorry to hear of your plight with both melanoma and breast cancer. You mention your concerns with your skin and radiotherapy, and it sounds like a valid reason to consider. I chose a mastectomy over a lumpectomy, as I too was concerned about side effects of radiotherapy. I really wanted reconstructcion as well, and radiotherapy reduces your choices, because of damage to your skin. I have no regrets about my choice, and though they will not be able to guarantee 100% that you won't need radio till after the pathology, in many cases, mastectomy negates the need for radiotherapy. I have since gone on to have a second mastectomy after my chemo, and have now completed bilateral reconstruction with implants about 6 weeksa ago, and am very happy with my results. Good luck with your treatment plan. Love Chris xx