Hi:) I have been taking it for almost 2 years.The hot flushes were relentless in the beginning,but my oncologist said they would settle,and in the last 6 months they have really lessened.My skin is definitely drier,and I have what I call 'Tamoxifen fuzz' on the sides of my face.Another couple of ladies on here have also noticed this.Idid get leg cramps at night,but I take 2 Blackmores magmin each day,and I don't get them any more.So all in all,it's not bad at all for me.I would say you have to give your body time to adjust to it.All the best.Cheers Robyn.xox