Neratinib trial

Thank you all for your comments.  In my research many were stunned that the FDA in US approved the drug. In the initial trial it caused severe diarrheoa in 40  percent of the participants.  The trial I’m offered is taking it along with Imodium prophylaxis for 56 cycles. There are also all the common side effects of chemo drugs and lots of tests.  It can cause liver toxicity and heart damage.  My oncologist is running the trial and when I said I was probably going to go on it as 1-2 percent increase in non recurrence was better than nothing and I was helping cancer research he commented that he wanted people to do it for themselves.  To be selfish.  It will mean another 15 months of treatment and I’ve already had 16. anyway I have a bit of time but the major side effect is not pleasant and could impact on work.  Thank you all again