Neratinib trial

Hi @awhol as mentioned I am on a clinical trial for a different drug. The Pallas trial follows participants to see if the drug Palbociclib is effective as a preventative of reoccurrance in early, high risk ER+ bc and whether the side effects are manageable and tollerable. I struggled with the decision as I was at the end of mastectomy, chemo, radio and looking forward to no longer being a cancer patient. The list of side effects was frightening and sounded a lot like chemo, which upset me. The deciding factors for me were threefold. Firstly, not everyone gets offered an extra line of treatment, and I didn't want to regret turning it down if 'it' comes back. Secondly, I wanted to do my part in cancer research, as my lifesaving treatments were once trial drugs also. Thirdly, I can quit any time I want, so if it's too horrible, seeyalater! I've done 3 of 24 cycles. Side effects are far fewer than I expected. The first cycle I felt fine, with a bit of fatigue kicking in during the second and the third aches, pains and tingling fingertips. The drug can cause neutropeania, which delayed my second cycle. It is likely that my dose will be reduced and some of my side effects will ease. I believe the aches and pains are most likely Tamoxifen, hormone blocker, not the trial drug. Hope this helps a bit. Good luck with your choice xxx