@Cafrini60 I ‘ve been on Letrozole. 2 years now. My oncologist when prescribing it suggested I take Krill Oil tablets which I have daily - can’t really say if it’s helped however as am reluctant to stop.
I also was advised about bone thinning caused by Letrozole.I had been diagnosed some years beforehand with osteoporosis.As I had recently an osteoporotic fracture - a cracked rib - I was put on 6 monthly Prolia injections.Ihave had no issues with the injections and I discovered many women I knew also had same.I was taking Caltrate with Vitamin D but now only take Vit D3 as there has been concerns from cardiologists about heart problems caused by calcium supplements.I noted Osteoporosis Australia no longer recommends Calcium supplements in their Clinical guidelines for this reason.
My issues have been minor and settled reasonably well after a few months.They were joint stiffness in the morning and a few hot flushes.I found/ find a daily one hour walk helped considerably to walk thru the joint stiffness.
I too have vaginal atrophy which is problematical as I need annual Pap smears.My onc has approved oestrogen pessaries for 5 days prior to my pap to help ensure a reading can be made.
I have had 2 other issues which may/may not be related to Letrozole.This year I have had very painful tennis elbow for 6 months - Letrozole can cause tendon issues like carpal tunnel and trigger thumb - tennis elbow is a repetitive strain injury effecting the tendon.
AlsoI have had problems with preexisting glaucoma no longer being controlled with drops necessitating eye surgery - Iam unsure if that is Letrozole but do know Tamoxifen has eye side effects.
Almost forgot Letrozole did cause a spike in my cholesterol which has formerly been quite low.
Finally I have noted a difference for me in the brands of Letrozole I have taken - currently I have used 3 .They say the difference in brands is the drug fillers and coatings which causes difficulties for people. I believe that is true for me with one particular brand - there are about 8 brands of Letrozole on the market in Australia.