@Glynnis. I had Letrozole for 6 months and got terrible migraines lasting 10 hours and nothing would touch them also they exasperated my lower back like bursitis. Lethargy was a corker. My oncologist changed me to Anastrozle. I now only have a few headaches, and a very sore thumb with a trigger joint. On the whole, feel heaps better. It's a case of which of the symptoms can you live with as they all have their varieties of symptoms. Rather than live with such quickly acquired symptoms so soon after starting, maybe an early appointment with your oncologist could see your meds changed They all basically do the same job but some suit others better. Oncologists come in all shapes and sizes and mines a real sweetie and she always says I can have an unscheduled appointment whenever I want if I have concerns. Regardless, a change might suit you better.