Hi Romla I've been on letrozole for 5 months and have regular bouts of fatigue, I'm working 4 days a week and exercise quite a lot mostly cycling but also now doing weights with a PT . As soon as I do much more than that I end up fatigued and spend the weekend trying to recover. The fatigue includes a very fussy head like a headache but not quite, sometimes I panic and think the cancer has spread to my brain . I don't know if the fussy head and fatigue are caused by letrozole or not. I know I'm meant to pace myself but like to live a busy life too. I've given up a lot of things I used to do , like committees and have also stopped working really long hours like I used to (both good things to reduce) I need to increase my hours to 5 days a week soon and wonder how I will manage. How have you managed FT work Kath? Lucky for me I didn't have chemo but did have radio which wasn't really the doddle I expected. Lyn