Hi @PV123 I don’t mind you asking at all. I was started on Tamoxifen because I was pre-menopausal when all this happened and that’s usually what they put you on. During the six months I was on it I had dreadful anxiety, fogginess, panic and finally suicidal thoughts. By then I had moved into menopause so I was changed to Arimidex. It was much better but I couldn’t sleep and my work was suffering. So the onc said let’s try and tweak that so we tried Aromasin, but that put me right back at the anxiety and panic again. This was confusing because it’s a different family of drugs to the Tamoxifen so evidently shouldn’t have done that. So the final drug to try was Letrozole. It’s taken away the mental symptoms but does give me the aches when I get out of bed each morning and my bone density has diminished slightly so now that will be monitored. But everyone is different as you will read here and everyone reacts differently. The important thing is to navigate your own path with the help of your Onc, GP, Physio etc. They are all there to help you but only you know how you’re feeling and you need to be the voice. I put up with Tamoxifen for six months because I thought that’s what I had to do and the side effects were what I had to live with. It’s not an easy journey but I’m thankful for early detection and having treatment available. I am so much more fortunate than others. Take care xxx