Forum Discussion
Ki67 results versus results from oncotype, etc tests
Hi!
First time stepping out from lurking and I just want to say thanks to everyone who has posted/commented anything on here. It has been so good to read about real (and Australian) BC experiences. I promise I'm going to add some photos in the Choosing Reconstruction group soon to pay forward the support.
I'm 45yo and 2.5 weeks ago had a single mastectomy with immediate implant reconstruction plus sentinel node biopsy on my right side after a diagnosis of invasive ductal carcinoma. Due to the size, it was hoped my nodes would be clear - which they thankfully were, hence the immediate reconstruction. That took radiotherapy off the treatment table, as I'd hoped when opting for a mastectomy.
I had no symptoms of cancer. I had a small lump pop up, red and sore, earlier this year. It was nowhere near my cancer and has since been determined to have been a cyst. But in checking it out, they found a patch of microcalcifications. Nothing could be seen on ultrasound nor palpated. I had a sterotactic biopsy and mri prior to surgery.
Following surgery, I had my first appointment with the medical oncologist this week and, unexpectedly, the team had decided that I should be given the option of Chemo. So now my head is swimming with statistics and so on.
Specifics of my tumour is 35mm at its widest (which matched the MRI, which had it at 35mm x 25mm x 10mm - quite flat which I assume is why no lump could be felt). It is strongly ER and PR positive. I have a history of lean PCOS (a hormonal condition) and taking the pill, Yasmin - so some hormonal risk factors. It is HER2 negative. There were no other tumours etc found in the rest of the breast and as mentioned, nodes clear.
So hormone therapy is 100% first line of attack for keeping it away. However, due to my younger age (I don't feel that young, but in the breast clinic waiting room I could see that I am in the world of breast cancer) and the size of the tumour, they wanted to give me the option of TC chemo.
I'm definitely in the 'oncotype testing recommended' group as it is not clear cut that chemo will do that much.
So my question. My Ki67 was 9%. Which is low (just). I'd love to hear from anyone who had any form of oncotype (or the other similar ones) testing. How did your Ki67 compare to your final tests?
I'm thankfully in a position to be able to afford the test - it would cost less than days off for chemo now that I've used all my sick leave. Just concerned as so far this has all been a slow process and I don't want too many more delays.
First time stepping out from lurking and I just want to say thanks to everyone who has posted/commented anything on here. It has been so good to read about real (and Australian) BC experiences. I promise I'm going to add some photos in the Choosing Reconstruction group soon to pay forward the support.
I'm 45yo and 2.5 weeks ago had a single mastectomy with immediate implant reconstruction plus sentinel node biopsy on my right side after a diagnosis of invasive ductal carcinoma. Due to the size, it was hoped my nodes would be clear - which they thankfully were, hence the immediate reconstruction. That took radiotherapy off the treatment table, as I'd hoped when opting for a mastectomy.
I had no symptoms of cancer. I had a small lump pop up, red and sore, earlier this year. It was nowhere near my cancer and has since been determined to have been a cyst. But in checking it out, they found a patch of microcalcifications. Nothing could be seen on ultrasound nor palpated. I had a sterotactic biopsy and mri prior to surgery.
Following surgery, I had my first appointment with the medical oncologist this week and, unexpectedly, the team had decided that I should be given the option of Chemo. So now my head is swimming with statistics and so on.
Specifics of my tumour is 35mm at its widest (which matched the MRI, which had it at 35mm x 25mm x 10mm - quite flat which I assume is why no lump could be felt). It is strongly ER and PR positive. I have a history of lean PCOS (a hormonal condition) and taking the pill, Yasmin - so some hormonal risk factors. It is HER2 negative. There were no other tumours etc found in the rest of the breast and as mentioned, nodes clear.
So hormone therapy is 100% first line of attack for keeping it away. However, due to my younger age (I don't feel that young, but in the breast clinic waiting room I could see that I am in the world of breast cancer) and the size of the tumour, they wanted to give me the option of TC chemo.
I'm definitely in the 'oncotype testing recommended' group as it is not clear cut that chemo will do that much.
So my question. My Ki67 was 9%. Which is low (just). I'd love to hear from anyone who had any form of oncotype (or the other similar ones) testing. How did your Ki67 compare to your final tests?
I'm thankfully in a position to be able to afford the test - it would cost less than days off for chemo now that I've used all my sick leave. Just concerned as so far this has all been a slow process and I don't want too many more delays.
29 Replies
- Woohoo @Pommy8, that's fantastic news!!
- My k67 score was 58% but oncoytype result came back low no chemo.
- You would think they would offer all of them. Thanks
- Thank you x
- I did a lot of Googling when I was offered the EndoPredict, as prior to that I had only heard of the Oncotype one. I was worried that because it's cheaper it may be 'less'. However, the studies I found and in some of the information for doctors on their website (Myriad Genetics) show that it more accurately predicts risk.
For all intents and purposes, OncotypeDX, EndoPredict, Prosignia all test the genetics of the tumour based on what is known about tumour growth. They analyse the tumour cells and give a score that can help when deciding if benefits outweigh risks of chemo. They do not test patient genetics (eg. will not identify BRAC etc risks).
If you google "Oncotype vs Endopredict" you'll get heaps of side-by-side comparisons too. - What's the difference between the oncotype test and endopredict test?
- Thanks @FLClover - your emojis sum up how I'm feeling perfectly!!!
- Yeah @StrongCoffee!! Woohoo!!! 🥳🥳🥳🥳😀😀
- I just wanted to update as I got my Endopredict results and my EPClin score was 3.1 with a long term recurrence risk of 8%. So my initial tests did line up to the genomic test results. Both being towards the upper end of the low risk range. This means chemo is not recommended! I'm so relieved!
