Hi @Hendrix, my fingers and toes are crossed for you that docetaxel will be kind to you. I have just had my second cycle of docetaxel today but I had a 25% dose reduction as I had all sorts of issues starting day 4 after infusion. I felt quite good for the first few days and like @TonyaM mentioned I too felt like road kill and like @Zoffiel it also did horrible things to my intestines along with oral thrush, an irritatingly itchy rash, really bad bone/muscle pain and lost all taste among other things. I don't want to put you off, like @melclarity I too am drug sensitive so I do tend to react badly anyway. As the other girls have said we all react differently to these f**** drugs they give us to treat this f***** disease (sorry hope I don't offend anyone but it's how I feel tonight). Maybe just have the panadol or something stronger if you need on standby for day 4 and be kind to yourself. I have know others to find docetaxel to be much easier. I am wishing this for you too. Best of luck and remember, you can do this. I went back for round two even though my first round was totally shitty.