I settled into taking mine during the middle of the day. I find I am naturally active during the day and whether it is mind over matter or not I feel being active keeps your mind off it and it's effects. I did try at night but struggled to settle into sleep, and I am a good sleeper, never really lost much sleep through all of this. I take other medication in the mornings so I didn't want one to counteract the other! It's what's suits! Honestly it's not that bad it's about adjusting to it. I did find one month I couldn't get my preferred brand and had an alternative, generic, goodness...............what a mistake that was! Body was not happy for the change!