@sickgirl Always check with your oncologist before taking a drug holiday, but my oncologist said a study had been done which showed that taking it three months on/three months off made no difference to outcomes. They don't recommend it because it becomes too difficult to maintain as a drug taking regime. These drugs are so difficult for many that the doctors recognise the benefits of letting patients take a month off once every year or so. Some people have reduced side effects when they recommence taking the drug as well. K xox