Hi there @Pommy...I've been on letrozole since mid 2017, so just over five years now. I have pre existing joint, tendon, muscle and skin issues due to scleroderma. My symptoms are no worse than either I, or my rheumatologist would have expected with the natural deterioration of this lifelong autoimmune condition. I also had osteoporosis before starting letrozole, due to a very early menopause (before age 38) and having been on prednisolone for over ten years.I have had two different ribs break on two different occasions, without fall or injury and for this I have a six monthly Prolia injection to help my bones, and my numbers have actually improved a tad. I'm of the opinion that had I not already had these other issues, my experience with letrozole would have been quite manageable. It still is manageable and I'll continue with them for at least another five years. Good luck with your ongoing treatment.