Was interested to read your blog. I am on Arimidex after taking Tamoxifen for 4 years. When I received the diagnosis of secondary cancer in a lymp node the specialist put me straight on Arimidex. I have been on it for a year now. I have had surgery, radiation and chemo in the past 15 months whilst taking the Arimidex (intermittently as I stopped whilst on chemo). I am nearly due to have my first mammogram and ultrasound since my Dec 2010 diagnosis. Of course I am a bit "scared" hoping that the radiation, chemo and Arimidex have done their jobs. Can I ask you how you knew the Arimidex wasn't working for you? The Arimidex give me heaps of aches and pains but I am struggling on with it (don't like the alternative). I would love to hear from you as I see my oncologist on Thursday and would like to ask him a few questions about this drug as opposd to Arimidex. Look forward to hearing from you. XLeonie