Endocrine therapy compared to menopause

Hi @Clancy.  I should finish my course of radiation therapy next week and will start Letrozole a couple of weeks after that. I’ll certainly post once I have some feedback on how I tolerate Letrozole. You mention that you are probably perimenopausal and my understanding is that women who haven’t been through menopause are normally put, as you say, on tamoxifen. I don’t know whether the effects of tamoxifen/ aromatase inhibitors are more profound on pre-menopausal ladies because they still have a greater supply of estrogen than post-menopausal ladies. I wonder whether @arpie or @Afraser, who are such fonts of knowledge on this forum, have any insights?