Interesting to read the difference in advice. My onc told me at the first review 2 weeks (I think) post-chemo that I could start the Letrozole as soon as I felt that I was ready but that he would prefer me to be on it sooner rather than later and that starting before or during rads would be fine. I'm guessing that a strong OR+ path result has something to do with that. But I do get the issue about confusion of symptoms. I've still got stuff going on around chemo and now possibly with rads as well - who knows what's related to Letrozole?