I'm also in the early days of Letrozole and extremely thankful for the observations of my oncologist who, in a forthright disclosure, warned me of the range of possible side effects. Due to lifelong physical disabilities including partial paralysis, I am no stranger to referred muscular and skeletal pain & at present really can't determine any significant change to the usual; perhaps that may come. My biggest challenge is how tired I am & how little exercise I seem to be able to do. It's frustrating because although my mobility is impaired, I have always worked hard at daily exercise to ensure I get around. Any suggestions on dealing not only with tiredness but exhaustion are welcome. Oh, and cheers to all from sunny Gold Coast !